The cheapest airline(s) flying from Santiago to Guayaquil is LATAM .
Guayaquil
A city undeserving of its transient reputation has more to offer than being the gateway to the Galapagos Islands. The developing metropolis prides itself as Ecuador’s commercial hub, dotted with unparalleled views of vibrant favelas. No day would be complete without a stroll by the soul of the city—the Malecon riverfront—to catch the bewitching sunset nuzzling the River Guayas.
Fare Guide for Santiago to Guayaquil Flights
Estimated lowest fares found within 7 days
Cheapest Airline
Cheapest Month
October
Cheapest Day of the Week
Monday
Cheapest Time
12am
Cheapest Airline
Cheapest Month
October
Travel Period: May 2025 - April 2026
The cheapest month(s) to fly from Santiago to Guayaquil is October.
Cheapest Day of the Week
Monday
The cheapest day(s) of the week to fly from Santiago to Guayaquil is Monday.
Cheapest Time
12am
The cheapest time of the day to fly from Santiago to Guayaquil is in the early morning.
Early Morning 12:01am - 06:00am
Morning 6:01am - 12:00pm
Afternoon 12:01pm - 6:00pm
Evening 6:01pm to 12:00am
12am
6am
12pm
6pm
Top 10 Hotels in Guayaquil
Hotel Ramada
Guayaquil City Center
7.9
909 reviews
Get rates
#1
Hotel Sol de Oro
Guayaquil City Center
8.0
43 reviews
Get rates
#2
Unipark Hotel by Oro Verde Hotels
Guayaquil City Center
8.7
1361 reviews
Get rates
#4
Oro Verde Guayaquil
Guayaquil City Center
9.0
3577 reviews
Get rates
#5
Wyndham Guayaquil Puerto Santa Ana
Guayaquil City Center
8.9
2342 reviews
Get rates
#6
TRYP by Wyndham Guayaquil Airport
Guayaquil City Center
8.7
2479 reviews
Get rates
#7
Sheraton Guayaquil Hotel
Guayaquil City Center
8.8
1359 reviews
Get rates
#8
Grand Hotel Guayaquil, Ascend Hotel Collection
Guayaquil City Center
8.8
1479 reviews
Get rates
#9
Radisson Hotel Guayaquil
Guayaquil City Center
9.0
1346 reviews
Get rates
#10
Wyndham Garden Guayaquil
Guayaquil City Center
8.8
2633 reviews
Get rates
#11